Discolouration in 3 of my toes and an open sore on my ankle. poor circulation , hardening of arteries- cause?

I am disabled so not very active lifestyle. How do i heal ankle. I have tried dry dressings, polysporin, peroxide, epson salts in bath water and now ozonol. Just starts to heal up then breaks open again.I wear a left leg-ankle brace . They have adjusted and made it wider to stop binding so trying to get it to stay healed. Am I doing the wrong treatment, something missing from diet, any natural oils,lotions, potions i should be using..could use any advice.